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Successful liver transplantation in a patient with severe haemophilia A and a high‐titre factor VIII inhibitor
Author(s) -
Ashrani A. A.,
Reding M. T.,
Shet A.,
Osip J.,
Humar A.,
Lake J. R.,
Key N. S.
Publication year - 2004
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/j.1365-2516.2004.01030.x
Subject(s) - medicine , haemophilia , haemophilia a , liver transplantation , titer , hepatocellular carcinoma , immune tolerance , transplantation , orthotopic liver transplantation , gastroenterology , surgery , immune system , immunology , antibody
Summary. We present the case of a 61‐year‐old man with severe haemophilia A and a high‐titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high‐titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.