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LKB 1 and AMP ‐activated protein kinase: regulators of cell polarity
Author(s) -
Nakano Atsushi,
Takashima Seiji
Publication year - 2012
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/j.1365-2443.2012.01629.x
Subject(s) - ampk , protein kinase a , cell polarity , biology , microbiology and biotechnology , polarity (international relations) , amp activated protein kinase , adenosine monophosphate , cell , kinase , adenosine , biochemistry
Adenosine monophosphate–activated protein kinase ( AMPK ), a metabolic protein kinase, and its upstream kinase LKB 1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB 1 and AMPK in cell polarity.