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Inheritance and memory of stress‐induced epigenome change: roles played by the ATF‐2 family of transcription factors
Author(s) -
Seong KiHyeon,
Maekawa Toshio,
Ishii Shunsuke
Publication year - 2012
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/j.1365-2443.2012.01587.x
Subject(s) - epigenetics , biology , epigenome , inheritance (genetic algorithm) , genetics , transcription factor , epigenesis , fight or flight response , dna methylation , gene , gene expression
Data on the inheritance‐of‐stress effect have been accumulating and some mechanistic insights, such as epigenetic regulation, have also been suggested. In particular, the modern view of Lamarckian inheritance appears to be affected by the finding that stress‐induced epigenetic changes can be inherited. This review summarizes the current data on the inheritance of stress effect and possible mechanisms involved in this process. In particular, we focus on the stress‐induced epigenetic changes mediated by the ATF‐2 family of transcription factors.