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KIAA1718 is a histone demethylase that erases repressive histone methyl marks
Author(s) -
Yokoyama Atsushi,
Okuno Yosuke,
Chikanishi Toshihiro,
Hashiba Waka,
Sekine Hiroki,
Fujiki Ryoji,
Kato Shigeaki
Publication year - 2010
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/j.1365-2443.2010.01424.x
Subject(s) - demethylase , histone methylation , biology , histone methyltransferase , histone , histone h2a , histone code , histone h1 , epigenetics , chromatin , genetics , microbiology and biotechnology , dna methylation , gene , gene expression , nucleosome
The methylation states of histone lysine residues are regarded as significant epigenetic marks governing transcriptional regulation. A number of histone demethylases containing a jumonji C (JmjC) domain have been recognized; however, their properties remain to be investigated. Here, we show that KIAA1718, a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for H3K9 and H3K27, transcriptionally repressive histone marks. Biochemical purification of the KIAA1718 interactants reveals that KIAA1718 forms complexes with several factors including KAP1, a transcriptional co‐activator. Consistent with these findings, KIAA1718 shows a transcriptional activation function in the chromatin context. Thus, our study identifies KIAA1718 as a histone demethylase for repressive methyl marks and shows that it is involved in transcriptional activation.