Premium
Tel2: a common partner of PIK‐related kinases and a link between DNA checkpoint and nutritional response?
Author(s) -
Kanoh Junko,
Yanagida Mitsuhiro
Publication year - 2007
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/j.1365-2443.2007.01142.x
Subject(s) - schizosaccharomyces pombe , biology , kinase , yeast , gene , genetics , saccharomyces cerevisiae , computational biology , microbiology and biotechnology
A recent paper (Hayashi et al . 2007) in this issue of Genes to Cells shows that the fission yeast Schizosaccharomyces pombe Tel2, a homologue of mammalian/worm CLK2/Clk‐2/Rad‐5, physically interacts with all the phosphoinositide 3‐kinase‐related kinases (PIKKs) that include Rad3/Tel1 (ATR/ATM homologues), Tor1/Tor2 (TOR kinases) and Tra1/Tra2 (TRRAP homologues), raising the possibility that Tel2 family proteins link various PIKK‐related cellular processes by interacting with PIKK family proteins. In this minireview, implications and impact of the findings, and a possibility that PIKKs are functionally related through Tel2, are discussed.