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Identification and characterization of a novel member of murine semaphorin family
Author(s) -
Taniguchi Masahiko,
Masuda Tomoyuki,
Fukaya Masahiro,
Kataoka Hirotaka,
Mishina Masayoshi,
Yaginuma Hiroyuki,
Watanabe Masahiko,
Shimizu Takao
Publication year - 2005
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/j.1365-2443.2005.00877.x
Subject(s) - semaphorin , biology , neuropilin , axon guidance , neuropilin 1 , plexin , dorsal root ganglion , microbiology and biotechnology , in situ hybridization , cerebellum , transmembrane protein , gene , neuroscience , axon , receptor , genetics , spinal cord , gene expression , cancer research , vascular endothelial growth factor , vegf receptors
The semaphorin gene family contains a large number of secreted type or transmembrane type proteins, and some of them function as the repulsive and attractive cues of axon guidance during development. Here we report a novel member of murine class 3 semaphorin genes, semaphorin 3G (Sema3G), mapped on chromosome 14. In adulthood, Sema3G is mainly expressed in the lung and kidney, and a little in the brain. Interestingly, in the adult rodent brain Sema3G is expressed only in the granular layer of the cerebellum, as determined by Northern blot and in situ hybridization analyses. We also found that Sema3G binds Neuropilin‐2, but not Neuropilin‐1, and induces the repulsion of sympathetic axons, but not dorsal root ganglion axons, indicating that Sema3G utilizes Neuropilin‐2 as a receptor to repel specific types of axons.