Premium
The various strategies within the TyrR regulon of Escherichia coli to modulate gene expression
Author(s) -
Pittard James
Publication year - 1996
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1111/j.1365-2443.1996.tb00012.x
Subject(s) - regulon , biology , escherichia coli , gene , genetics , escherichia coli proteins , microbiology and biotechnology , computational biology
The TyrR Regulon of Escherichia coli comprises eight transcription units whose expression is modulated by the TyrR protein. This protein, which is normally a homodimer in solution, can self‐associate to form a hexamer, bind with high affinity to specific DNA sequences (TyrR boxes) and interact with the α subunit of the RNA polymerase. These various reactions are influenced by the abundance of one or more of the aromatic amino acids, tyrosine, phenylalanine or tryptophan and by the specific location and sequence of the TyrR boxes associated with each transcription unit. This review describes how these activities can be combined in different ways to produce a variety of responses to varying levels of the three aromatic amino acids.