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Correlation of fasting serum apolipoprotein B‐48 with coronary artery disease prevalence
Author(s) -
Masuda Daisaku,
Sugimoto Taizo,
Tsujii Kenichi,
Inagaki Miwako,
Nakatani Kazuhiro,
YuasaKawase Miyako,
TsubakioYamamoto Kazumi,
Ohama Tohru,
Nishida Makoto,
Ishigami Masato,
Kawamoto Toshiharu,
Matsuyama Akifumi,
Sakai Naohiko,
Komuro Issei,
Yamashita Shizuya
Publication year - 2012
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2012.02687.x
Subject(s) - medicine , coronary artery disease , postprandial , apolipoprotein b , chylomicron , body mass index , cardiology , adiponectin , triglyceride , angiology , gastroenterology , endocrinology , coronary atherosclerosis , hyperlipidemia , lipoprotein , diabetes mellitus , cholesterol , insulin resistance , obesity , insulin , very low density lipoprotein
Eur J Clin Invest 2012; 42 (9): 992–999 Abstract Background Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM‐R). Many in vitro studies have shown that CM‐R has highly atherogenic properties, but consensus is lacking on whether CM‐R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM‐R accumulation and the prevalence of coronary artery disease (CAD). Design Subjects who received a coronary angiography and did not take any lipid‐lowering drugs ( n = 189) were enrolled. Subjects with coronary artery stenosis (≥ 75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B‐48 concentration were compared between CAD patients ( n = 96) and age‐, sex‐, and body mass index (BMI)‐matched non‐CAD subjects without overt coronary stenosis (< 75%) ( n = 67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B‐48 and other coronary risk factors (high triglyceride, low HDL‐C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results Fasting serum apo B‐48 levels were significantly higher in CAD patients than in non‐CAD subjects (3·9 ± 2·4 vs. 6·9 ± 2·6 μg/mL, P < 0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B‐48 levels (> 4·34 μg/mL, the cut‐off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B‐48 levels. Conclusion Fasting serum apo B‐48 levels significantly correlated with the prevalence of CAD.