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IL28B and interferon‐gamma inducible protein 10 for prediction of rapid virologic response and sustained virologic response in HIV‐HCV‐coinfected patients
Author(s) -
Payer Berit A.,
Reiberger Thomas,
Aberle Judith,
Ferenci Peter,
Holzmann Heidemarie,
Rieger Armin,
PeckRadosavljevic Markus
Publication year - 2012
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2011.02623.x
Subject(s) - ribavirin , medicine , gastroenterology , snp , immunology , virology , single nucleotide polymorphism , genotype , hepatitis c virus , virus , biology , gene , biochemistry
Eur J Clin Invest 2012; 42 (6): 599–606 Abstract Background A polymorphism near the IL28B gene has been shown to be associated with virologic response to antiviral treatment in HCV‐infected patients. The predictive value of interferon‐gamma inducible protein 10 (IP10) on treatment outcome has been described in HCV patients. Data on combining these predictors in HIV‐HCV‐coinfected patients are not available. Methods Virologic parameters, IL28B single nucleotide polymorphisms (SNP) and pretreatment serum IP10 were determined in HIV‐HCV‐coinfected patients having completed antiviral therapy with pegylated interferon/ribavirin. Results A total of 72 HIV‐HCV‐coinfected patients were included in the study; 68% had HCV genotype (GT)‐1/4 and 32% had HCV GT‐2/3 infections. Rapid virologic response (63% vs. 28%; P = 0·023) and sustained virologic response (SVR: 81% vs. 51%; P = 0·008) rates were significantly higher in C/C vs. non‐C/C patients. Patients with low pretreatment IP10 levels (< 400 pg/mL) achieved significantly higher SVR rates than patients with high (> 400 pg/mL) IP10 levels (78% vs. 13%; P < 0·0001). C/C SNP and low IP10 levels were associated with higher SVR rates in both patients with GT‐1/4 and GT‐2/3. The C/C patients with low IP10 achieved SVR rates of 97% compared with SVR rates of 9% in non‐C/C patients with high IP10. Conclusion The IL28B SNP influences rapid viral response, relapse rates and SVR. The combination of IL28B and IP10 represents a predictive model of SVR in HIV‐HCV coinfection.