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Elevated E‐selectin and diastolic blood pressure in diabetic children
Author(s) -
Maggio Albane B. R.,
FarpourLambert Nathalie J.,
Montecucco Fabrizio,
Pelli Graziano,
Marchand Laetitia M.,
Schwitzgebel Valérie,
Mach François,
Aggoun Yacine,
Beghetti Maurice
Publication year - 2012
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2011.02583.x
Subject(s) - medicine , blood pressure , diastole , triglyceride , endocrinology , body mass index , type 1 diabetes , ambulatory blood pressure , biomarker , diabetes mellitus , selectin , cardiology , cholesterol , inflammation , biology , biochemistry
Eur J Clin Invest 2012; 42 (3): 303–309 Abstract Background Cardiovascular risk markers are related to micro‐angiopathy in children with type 1 diabetes (T1DM), but there is no information about their relationship with blood pressure (BP) and endothelial function. Materials and methods This was a case–control study including 29 children with T1DM (mean age 10·5 ± 2·7 years, disease duration: 3·8 ± 2·2 years) and 39 healthy controls (mean age: 9·8 ± 2·7 years). We assessed 24‐h ambulatory BP, vascular function and serum level of lipids, vascular cell adhesion molecule‐1 (VCAM‐1; ICAM) and selectins (E‐selectin; P‐selectin). Results The subject groups had similar physical characteristics and lipids level, except body mass index (BMI) which was higher in T1DM than in healthy children (18·6 ± 2·6 vs. 16·7 ± 2·5 kg/m 2 , P = 0·003). Children with T1DM had increased 24 h diastolic BP z ‐score (0·62 ± 0·9 vs. −0·65 ± 0·8, P < 0·001), even after adjustment for BMI, as well as higher VCAM‐1 concentration (492 ± 346 vs. 340 ± 225 ng/mL, P = 0·039) compared to healthy subjects. Diastolic BP z ‐scores were associated with disease duration, E‐selectin and triglyceride levels in the T1DM group ( P < 0·05). E‐selectin was also related to triglycerides, otherwise there were no relationships between vascular function, markers and BP. Conclusion E‐selectin, an early atherosclerosis biomarker, is positively associated with diastolic BP values in children with T1DM, despite relatively short disease duration.