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Prognostic role of microRNA‐21 in various carcinomas: a systematic review and meta‐analysis
Author(s) -
Fu Xiaonan,
Han Yijie,
Wu Ying,
Zhu Xiaoli,
Lu Xin,
Mao Feng,
Wang Xuejing,
He Xuelian,
Zhao Yuhang,
Zhao Yulan
Publication year - 2011
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2011.02535.x
Subject(s) - hazard ratio , meta analysis , medicine , oncology , microrna , head and neck squamous cell carcinoma , subgroup analysis , cancer , carcinoma , head and neck cancer , survival analysis , confidence interval , biology , gene , biochemistry
Eur J Clin Invest 2011; 41 (11): 1245–1253 Abstract Background Recent studies have shown that microRNAs (miRNA) could play a potential role as diagnostic and prognostic biomarkers of cancers. The aim of this meta‐analysis is to summarize the global predicting role of miR‐21 for survival in patients with a variety of carcinomas. Design Eligible studies were identified and assessed for quality through multiple search strategies. Data were collected from studies comparing overall, relapse‐free or cancer‐specific survival (CSS) in patients with cancer having higher miR‐21 expression with those having lower levels. Pooled hazard ratios (HRs) of miR‐21 for survival were calculated. Results A total of 17 studies dealing with various carcinomas were included for this global meta‐analysis. For overall survival (OS), the pooled hazard ratio (HR) of higher miR‐21 expression in cancerous tissue was 1·69 (95% CI: 1·33–2·16, P < 0·001), which could significantly predict poorer survival in general carcinomas. For relapse‐free or CSS, elevated miR‐21 was also a significant predictor, with a pooled HR of 1·48 (95% CI: 1·03–2·11, P = 0·033). Importantly, subgroup analysis suggested that higher expression of miR‐21 correlated with worse OS in head and neck squamous cell carcinoma (HNSCC) (HR 1·46, 95% CI: 1·13–1·87, P = 0·004) and carcinomas in digestion system (HR 1·56, 95% CI: 1·08–2·26, P = 0·018). Conclusions Our findings suggest that miR‐21 detection has a prognostic value in patients with cancer, especially in HNSCC and digestion system cancers.