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MRP8/14 is associated with systemic inflammation in stable coronary atherosclerosis in men
Author(s) -
Baumann Marcus,
Schmaderer Christoph,
Burkhardt Klaus,
Haller Bernhard,
Heemann Uwe,
Dugi Klaus,
von Eynatten Maximilian
Publication year - 2011
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2011.02530.x
Subject(s) - coronary artery disease , medicine , inflammation , systemic inflammation , fibrinogen , c reactive protein , coronary angiography , cardiology , phagocyte , coronary atherosclerosis , gastroenterology , immunology , myocardial infarction , immune system
Eur J Clin Invest 2011; 41 (12): 1261–1267 Abstract Background MRP8/14, a secreted heterodimeric protein complex secreted upon phagocyte activation, plays an important role in atherogenesis and vascular injury. Phagocyte activation is crucially involved in the development of atherosclerotic processes, and MRP8/14 levels have also been linked to acute cardiovascular events. We investigated whether circulating MRP8/14 correlates to chronic coronary artery disease (CAD) stages in this observational, cross‐sectional study. Methods and results A total of 240 male subjects undergoing elective coronary angiography were included in the study. CAD was present in 166 individuals, whereas 74 subjects were classified without prevalent CAD (control subjects). The atherosclerotic burden was obtained by three independent angiographic scores: the Severity, Gensini and Extent Score. Serum MRP8/14 levels were measured by ELISA. They were associated with hs‐CRP, IL‐6 and fibrinogen levels ( r = 0·43, r = 0·40 and r = 0·44, respectively; all P < 0·001). However, MRP8/14 was neither associated with any other cardiovascular disease risk factor nor did serum levels differ between patients with stable CAD [0·82 (0·55–1·14) μg mL −1 ] and control subjects [0·91 (0·63–1·30) μg mL −1 ; P = 0·69]. Moreover, atherosclerotic wall irregularities did not demonstrate any association with circulating MRP8/14. Conclusions The phagocyte activation marker MRP8/14 is significantly associated with markers of systemic inflammation in male patients with CAD. However, we were unable to find a correlation between circulating MRP8/14 complex and stable CAD.