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Association between kidney and cardiac diastolic function in Chinese subjects without overt disease: correlation with ageing and inflammatory markers
Author(s) -
Han LuLu,
Bai XiaoJuan,
Lin HongLi,
Sun XueFeng,
Chen XiangMei
Publication year - 2011
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2011.02503.x
Subject(s) - medicine , renal function , quartile , cystatin c , ageing , percentile , diastole , cardiology , kidney disease , population , blood pressure , confidence interval , statistics , mathematics , environmental health
Eur J Clin Invest 2011; 41 (10): 1077–1086 Abstract Background Age‐related changes in kidney structure and function have been well documented. This study aimed to assess the relationship between declines of normal ageing‐related kidney function and cardiac diastolic function in a healthy Chinese population. Materials and methods A total of 852 healthy adults aged 30–98 years were enrolled and divided into four groups according to quartiles of estimated glomerular filtration rate (eGFR) and cystatin C (CYSC). Cardiac diastolic function was measured by ratio of peak velocity of early filling to peak velocity of atrial filling (E/A), which was derived by B‐mode echocardiography. Lower E/A was defined as measures under the 25th percentile of sample distribution (0·784). Results Age was significantly associated with eGFR ( r = −0·102, P < 0·01), CYSC ( r = 0·544, P < 0·01) and E/A ( r = −0·381, P < 0·01). Binary logistic regression analysis revealed that second, third and fourth quartile groups of CYSC and fourth quartile of eGFR were significantly associated with lower E/A in an unadjusted model. However, these associations were lost after full adjustment. Conclusions Our results confirm that ageing is a major factor contributing to declines in both kidney and cardiac diastolic function in a healthy population. Adjustment for covariates, however, showed that normal ageing‐related declines in kidney function and cardiac diastolic function are not independently linked.