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The effect of next‐generation sequencing technology on complex trait research
Author(s) -
DayWilliams Aaron G.,
Zeggini Eleftheria
Publication year - 2011
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2010.02437.x
Subject(s) - trait , computational biology , data science , quantitative trait locus , dna sequencing , biology , computer science , genetics , gene , programming language
Eur J Clin Invest 2011; 41 (5): 561–567 Abstract Background Advances in the understanding of complex trait genetics have always been enabled by advances in genomic technology. Next‐generation sequencing (NGS) is set to revolutionize the way complex trait genetics research is carried out. Results NGS has multiple applications in the field of human genetics, but is accompanied by substantial study design, analysis and interpretation challenges. This review discusses key aspects of study design considerations, data handling issues and required analytical developments. We also highlight early successes in mapping genetic traits using NGS. Conclusion NGS opens the entire spectrum of genomic alterations for the genetic analysis of complex traits and there are early publications illustrating its power. Continuing development in analytical tools will allow the promise of NGS to be realized.