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Lipid assessment, metabolic syndrome and coronary heart disease risk
Author(s) -
Arsenault Benoit J.,
Després JeanPierre,
Stroes Erik S. G.,
Wareham Nicholas J.,
Kastelein John J. P.,
Khaw KayTee,
Boekholdt S. Matthijs
Publication year - 2010
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2010.02357.x
Subject(s) - medicine , apolipoprotein b , cholesterol , lipoprotein , nuclear magnetic resonance spectroscopy , population , national cholesterol education program , high density lipoprotein , metabolic syndrome , chemistry , endocrinology , obesity , organic chemistry , environmental health
Eur J Clin Invest 2010; 40 (12): 1081–1093 Abstract Background Although the total to high‐density lipoprotein cholesterol ratio (TC/HDL‐C) has been used for decades to identify individuals at risk for coronary heart disease (CHD), apolipoprotein‐based (apolipoprotein B/apolipoprotein A‐I [apoB/apoA‐I]) and nuclear magnetic resonance spectroscopy (NMR)‐based lipoprotein concentrations (low‐density lipoprotein NMR /high‐density lipoprotein NMR [LDL NMR /HDL NMR ]) may also be useful for CHD risk stratification. Materials and methods In a case–control study conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC)‐Norfolk study population, 870 individuals who developed CHD during a 6‐year follow‐up were matched to 1659 controls on the basis of gender, age and enrolment time. LDL NMR and HDL NMR were measured by proton NMR spectroscopy. Results After adjusting for traditional CHD risk factors, men in the top quintile of the various lipoprotein ratios proved to be at increased CHD risk (OR = 2·59 [95% IC, 1·76–3·83] for TC/HDL‐C ratio, 2·59 [1·75–3·83] for apoB/apoA‐I ratio and 2·78 [1·86–4·17] for LDL NMR /HDL NMR ratio) compared with men in the bottom quintile. Similar associations were observed in women (OR = 2·86 [1·71–4·80] for TC/HDL‐C ratio, 2·94 [1·74–4·97] for apoB/apoA‐I ratio and 2·03 [1·21–3·43] for LDL NMR /HDL NMR ratio). Compared with participants with only one component of the metabolic syndrome, those who had five had an increased TC/HDL‐C ratio (73·0% and 80·4% in men and women respectively), apoB/apoA‐I ratio (58·0% and 62·9% in men and women respectively) and for LDL NMR /HDL NMR ratio (52·6% and 54·1% in men and women respectively). Conclusion In this European study population, the TC/HDL‐C, apoB/apoA‐I and LDL NMR /HDL NMR ratios were similarly associated with components of the metabolic syndrome and CHD risk.