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Effect of acute hyperglycaemia on sensory processing in diabetic autonomic neuropathy
Author(s) -
Frøkjær Jens B.,
Søfteland Eirik,
Graversen Carina,
Dimcevski Georg,
Drewes Asbjørn M.
Publication year - 2010
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2010.02335.x
Subject(s) - autonomic neuropathy , medicine , diabetic neuropathy , sensory system , diabetes mellitus , sensory processing , autonomic nervous system , physical medicine and rehabilitation , endocrinology , neuroscience , psychology , biology , heart rate , genetics , blood pressure , cell culture , neuroblastoma
Eur J Clin Invest 2010; 40 (10): 883–886 Abstract Background Acute hyperglycaemia is known to increase gastrointestinal (GI) sensitivity in healthy subjects and may contribute to the increased prevalence of GI symptoms in diabetes patients. The aim of this study was to evaluate the effect of acute hyperglycaemia on perception and brain responses to painful visceral and somatic stimuli in diabetic patients. Materials and methods The sensitivity and evoked brain potentials (EPs) to electrical oesophageal and median nerve stimulations were assessed in 14 type‐1 diabetes patients with autonomic neuropathy and GI symptoms using a hyperinsulinaemic clamp at 6 and 15 mM. Results No differences between the normo‐ and hyperglycaemic conditions were found in sensitivity to both oesophageal ( P = 0·72) and median nerve ( P = 0·66) stimulations. The latencies and amplitudes of EPs did not differ between the normo‐ and hyperglycaemic conditions following oesophageal ( P = 0·53 and 0·57) and median nerve ( P = 0·78 and 0·52) stimulations. Conclusions Acute hyperglycaemia itself does not contribute to the sensations in patients with longstanding diabetes and autonomic neuropathy. Any potential sensory effects of acute hyperglycaemia can likely be blurred by the neuropathic‐like changes in the sensory nervous system.