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Beclomethasone dipropionate blunts allergen‐induced early increase in urinary LTE4
Author(s) -
Bartoli Maria Laura,
Dente Federico Lorenzo,
Bancalari Lorenza,
Bacci Elena,
Cianchetti Silvana,
Di Franco Antonella,
Vagaggini Barbara,
Paggiaro Pier Luigi
Publication year - 2010
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2010.02297.x
Subject(s) - placebo , medicine , asthma , allergen , leukotriene e4 , urinary system , anesthesia , leukotriene , immunology , allergy , gastroenterology , pathology , alternative medicine
Eur J Clin Invest 2010; 40 (6): 566–569 Abstract Background The inhibitory effect of corticosteroids (CS) on the secretions of cysteinyl‐leukotrienes (Cys‐LTs) in asthma is controversial. The aim of this study was to evaluate the effect of CS on allergen‐induced increase in urinary leukotriene E4 (uLTE4) during early (EAR) and late (LAR) asthmatic responses in mild untreated asthmatics. Material and methods Nine subjects with mild untreated allergic asthma performed two allergen challenges, after 1‐week treatment with beclomethasone dipropionate (BDP, 500 μg b.i.d) or placebo. Forced Expiratory Volume in one second 1 (FEV1) was monitored to assess EAR and LAR, and uLTE4 was measured before and during EAR and LAR. Results After placebo, uLTE4 increased significantly during EAR, but not during and after LAR, in comparison with baseline values. Beclomethasone dipropionate induced a significant attenuation of the uLTE4 increase during EAR, in comparison with placebo, in association with a good protection of LAR ( P = 0·002) and a mild protection of EAR ( P = 0·07). Conclusions Beclomethasone dipropionate blunts the early increase in uLTE4 excretion due to allergen challenge, in association with a significant effect on the severity of LAR. These data support the hypothesis that inhaled CS may inhibit the allergen‐induced release of cys‐LTs in asthma.