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Expression of STAMP2 in monocytes associates with cardiovascular alterations
Author(s) -
Wang ZhiHao,
Zhang Wei,
Gong HuiPing,
Guo ZhongXiu,
Zhao Jing,
Shang YuanYuan,
Feng JinBo,
Zhang Yun,
Zhong Ming
Publication year - 2010
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2010.02288.x
Subject(s) - medicine , metabolic syndrome , monocyte , blood pressure , endocrinology , cardiology , gastroenterology , obesity
Eur J Clin Invest 2010; 40 (6): 490–496 Abstract Background Metabolic and inflammatory pathways crosstalk at many levels. In this study, we aimed to investigate the expression of six‐transmembrane protein of prostate 2 (STAMP2) in macrophages and tried to search for the association between the decreased STAMP2 expression, if any, and carotid atherosclerosis as well as cardiac adaptations. Materials and methods A total of 97 unrelated Chinese subjects were recruited including 48 subjects with metabolic syndrome (MetS) and 49 controls. Clinical and biochemical characteristics were collected from subjects, with quantification of STAMP2 in monocyte/macrophages. All subjects underwent ultrasonography. Results STAMP2 expression in macrophages was significantly decreased in MetS as compared with the control group (10·25 ± 9·20 vs. 15·20 ± 9·18, P = 0·009), especially in women patients. Partial correlation analysis showed that STAMP2 expression in macrophages correlated with BMI ( r = −0·375, P = 0·045), age ( r = 0·414, P = 0·026) and HDL ( r = 0·377, P = 0·044) after controlling for systolic blood pressure (SBP). Furthermore, STAMP2 expression was correlated with PI ( r = −0·454, P = 0·013), LVEF ( r = −0·503, P = 0·005), LA‐ESR ( r = −0·424, P = 0·022), LA‐S ( r = 0·469, P = 0·010) and mitral E/A ratio ( r = 0·492, P = 0·005) after controlling for SBP. Still, in multivariable analysis, STAMP2 expression was independently associated with IMT mean , PI and mitral E/A ratio. Conclusions In MetS patients, especially women patients, STAMP2 expression was down‐regulated in peripheral blood mononuclear cell, which was correlated with carotid atherosclerosis and cardiac adaptation.