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Endothelin receptor antagonism and cancer
Author(s) -
Bhalla A.,
Haque S.,
Taylor I.,
Winslet M.,
Loizidou M.
Publication year - 2009
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2009.02123.x
Subject(s) - receptor , stromal cell , endothelin receptor , cancer research , angiogenesis , prostate cancer , prostate , antagonism , medicine , biology , cancer
The endothelin peptides have an important role in the cancer‐stromal interactions that promote tumour growth. Endothelin‐1 (ET‐1), clinically the most investigated endothelin, is a vital agent in the growth and progression of several tumours including prostate, ovarian, colorectal, bladder, breast and lung carcinomas. ET‐1 exerts its effects through the activation of two distinct receptors, ET A and ET B . Once activated, these receptors transmit signals via numerous intracellular signalling pathways. The effects of ET receptor stimulation in cancer cells or cancer‐associated cells include proliferation, resistance to apoptosis, angiogenesis, migration and subsequent invasion. At present, the manipulation of the endothelin axis within the pre‐clinical setting is the subject of intense investigation. Recent studies into ET receptor antagonism have produced interesting results highlighting the fact that these receptors may provide novel targets for a new generation of chemotherapeutic agents in a variety of cancers.