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Erythropoietin and the endothelium – a promising link?
Author(s) -
Fliser D.,
Bahlmann F. H.
Publication year - 2008
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2008.01968.x
Subject(s) - erythropoietin , erythropoiesis , medicine , endothelium , pharmacology , recombinant dna , endocrinology , biology , anemia , biochemistry , gene
SUMMARY The major physiological function of erythropoietin (EPO) is thought to be the induction of erythropoiesis. However, a growing body of evidence indicates that EPO as well as recombinant human erythropoietin (rHuEPO) and its analogues have tissue‐protective effects and prevent tissue damage during ischaemia. This mini review summarizes the present knowledge on protective vascular effects of EPO and discusses the potential underlying mechanisms.