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Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome?
Author(s) -
Stejskal D.,
Karpisek M.
Publication year - 2006
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2006.01696.x
Subject(s) - medicine , metabolic syndrome , endocrinology , waist , body mass index , quantitative insulin sensitivity check index , population , insulin resistance , uric acid , insulin , obesity , insulin sensitivity , environmental health
Background Adipocyte fatty acid binding protein (A‐FABP) has been suggested as playing an important role in the pathogenesis of metabolic syndrome. The aim of this study was to evaluate serum A‐FABP as a marker of metabolic syndrome and to assess its predictive accuracy in a Caucasian population. Materials and methods Anthropometric and serum analyses were performed for body mass index (BMI), waist circumference, A‐FABP, insulin, triglycerides, total cholesterol, high‐density lipoprotein‐cholesterol (HDL‐c), low‐density lipoprotein‐cholesterol (LDL‐c), uric acid, and glucose on 67 non‐obese, healthy subjects and 71 subjects with metabolic syndrome. Quicki‐quantitative insulin sensitivity check index, receiver operating characteristic curve (ROC‐curve) and χ 2 analysis were completed. Results Compared with healthy controls, subjects with metabolic syndrome had a significantly higher A‐FABP serum level (mean: 42·4 vs. 23·7 µg L −1 ; P < 0·01). The A‐FABP serum level correlated with fasting levels of insulin ( r = 0·34; P < 0·01), glucose ( r = 0·21; P = 0·01), triglycerides ( r = 0·4; P < 0·01), BMI ( r = 0·57; P < 0·01) and waist circumference ( r = 0·51; P < 0·01), but negatively with HDL‐c ( r = – 0·23; P < 0·01) and Quicki ( r = – 0·32; P < 0·01). The relationship was defined between serum A‐FABP level and metabolic syndrome diagnosis with 40% sensitivity and 99% specificity at A‐FABP level 16·4 µg L −1 . Conclusions Serum A‐FABP level might be an independent marker of metabolic syndrome in a Caucasian population.