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Hyperleptinaemia and hypoadiponectinaemia are associated with gallstone disease
Author(s) -
Wang S. N.,
Yeh Y. T.,
Yu M. L.,
Dai C. Y.,
Chi W. C.,
Chung W. L.,
Lee K. T.
Publication year - 2006
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2006.01611.x
Subject(s) - adiponectin , medicine , leptin , endocrinology , obesity , overweight , triglyceride , adipose tissue , adipokine , cholesterol , insulin resistance
Background Gallstone disease has been regarded as an obesity‐related disease. Therefore, we hypothesized that leptin and adiponectin, mainly produced by adipose tissue, may play roles in gallstone disease. Patients and methods The RIA method was used to analyze serum leptin and adiponectin levels of 90 gallstone patients and 91 healthy subjects. Results Our results showed that BMI, fasting glucose, serum AST and ALT, and leptin were significantly increased in the gallstone patients as compared with the healthy subjects ( P < 0·001, P < 0·001, P < 0·001, P < 0·001, P < 0·001, and P = 0·013, respectively). Intriguingly, serum adiponectin was the only variable to be significantly decreased in the gallstone patients ( P = 0·002). Furthermore, serum AST, leptin, and adiponectin were significantly associated with gallstone disease ( P < 0·001, P = 0·021, and P = 0·006, respectively). Overweight (BMI ≥ 25 kg m −2 ), but not normal‐weight, gallstone patients had an increased serum leptin and a decreased serum adiponectin level as compared with matched healthy subjects ( P < 0·001 and P = 0·024, respectively). In addition, serum leptin was positively correlated with BMI and serum cholesterol, while serum adiponectin was inversely correlated with serum triglyceride in the gallstone patients. Conclusions Our study indicated that hyperleptinaemia and hypoadiponectinaemia might be involved in the occurrence of gallstone disease. However, the causal relationship of hyperleptinaemia and hypoadiponectinaemia with gallstone disease might require further investigation.