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Erythropoiesis and red cell function in vertebrate embryos
Author(s) -
Baumann R.,
Dragon S.
Publication year - 2005
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.2005.01524.x
Subject(s) - erythropoiesis , vertebrate , biology , function (biology) , embryo , embryonic stem cell , microbiology and biotechnology , population , evolutionary biology , gene , genetics , medicine , anemia , environmental health
All vertebrate embryos produce a specific erythroid cell population – primitive erythrocytes – early in development. These cells are characterized by expression of the specific embryonic haemoglobins. Many aspects of primitive erythropoiesis and the physiological function of primitive red cells are still enigmatic. Nevertheless, recent years have seen intensive efforts to characterize in greater detail the molecular events underlying the initiation of erythropoiesis in vertebrate embryos. Several key genes have been identified that are necessary for primitive and the subsequent definitive erythropoiesis, which differs in several aspect from primitive erythropoiesis. This review gives in its first part a short overview dealing with comparative aspects of primitive and early definitive erythropoiesis in higher and lower vertebrates and in the second part we discuss the physiological function of primitive red cells based mainly on results from mammalian and avian embryos.