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Serial changes in serum vitamin K 1 , triglyceride, cholesterol, osteocalcin and 25‐hydroxyvitamin D 3 in patients after hip replacement for fractured neck of femur or osteoarthritis
Author(s) -
ROBERTS N. B.,
HOLDING J. D.,
WALSH H. P. J.,
KLENERMAN L.,
HELLIWELL T.,
KING D.,
SHEARER M.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1996.tb02382.x
Subject(s) - osteocalcin , triglyceride , medicine , endocrinology , vitamin d and neurology , hip fracture , femur , osteoarthritis , vitamin , population , cholesterol , osteoporosis , surgery , chemistry , biochemistry , alkaline phosphatase , pathology , alternative medicine , environmental health , enzyme
. Serum vitamin K 1 concentrations were measured at presentation (just before surgery) and then at weekly intervals for 3 weeks in two groups of elderly patients requiring either hemiarthroplasty for fractured neck of femur (FON, n = 13) or total hip replacement for osteoarthritis of the hip (OA, n = 16). In comparison with healthy elderly volunteers ( n = 25), serum vitamin K 1 concentrations were significantly lower in both groups at presentation, and fell significantly within 24 h after surgery to concentrations approaching non‐detectable, subsequently returning to pre‐operative values within 3 weeks. Serum vitamin K 1 tended to be lower in the fracture group both before and after operation, although calculation of a vitamin K 1 –triglyceride ratio reduced the apparent difference as triglyceride concentrations were lower in the fracture group. Osteocalcin concentrations were similar and fell significantly after operation in both groups, returning to pre‐operative levels within 7 days. No differences in the two forms of osteocalcin (carboxylated and undercarboxylated) were observed either before or after operation in either group. 25‐Hydroxyvitamin D 3 concentrations were not significantly different between the two groups at any time. Vitamin K 1 status may be lower than desirable in certain groups of the elderly population, and supplementation should be considered as prophylactic therapy.