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Longitudinal analysis of soluble intercellular adhesion molecule 1 in retinal vasculitis patients
Author(s) -
PALMER H. E.,
ZAMAN A. G.,
ELLIS B. A.,
STANFORD M. R.,
GRAHAM E. M.,
WALLACE G. R.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1996.tb02154.x
Subject(s) - intercellular adhesion molecule 1 , retinal , intracellular , cell adhesion molecule , intercellular adhesion molecule , retinal vasculitis , vasculitis , adhesion , medicine , chemistry , pathology , cell adhesion , immunology , ophthalmology , biochemistry , disease , organic chemistry
. Increased levels of soluble intercellular adhesion molecule 1 (sICAM‐1) in serum have been demonstrated in several human disease conditions. We have previously shown, in a point‐prevalence study, a positive correlation between sICAM‐1 levels and disease relapse in patients with idiopathic retinal vasculitis. We now report a longitudinal study over 1 year in which sICAM‐1 levels were compared with clinical disease status in order to determine this relationship further. Serum samples from 11 patients with idiopathic retinal vasculitis were tested for the presence of sICAM‐1 by enzyme linked immunosorbent assay. Eight control subjects were also tested. Five out of 11 patients presented with relapse and had raised sICAM‐1 levels compared with quiescent periods of their disease. Five out of 11 patients showed no relapse over 1 year and also no increase in sICAM‐1 levels. One patient showed increased levels of sICAM‐1, but no clinical signs of relapse. These results indicate that sICAM‐1 is associated with disease activity in retinal vasculitis patients and could indicate dysfunction of the blood‐retina barrier.