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Studies in hypertriglyceridaemia, III: glucose tolerance, insulin sensitivity and indices of adipose tissue lipolysis in randomly selected non‐diabetic hypertriglyceridaemic Swedish men
Author(s) -
ASPLUNDCARLSON A.
Publication year - 1995
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1995.tb01956.x
Subject(s) - medicine , endocrinology , lipolysis , insulin resistance , insulin , body mass index , diabetes mellitus , insulin sensitivity , impaired glucose tolerance , adipose tissue
. Hypertriglyceridaemia, insulin resistance and glucose intolerance are conditions associated with an increased risk of coronary heart disease. In this study we have examined randomly selected non‐diabetic hypertriglyceridaemic (HTG) males, 40–50 years ( n = 65) and age‐matched normotriglyceridae‐mic (NTG) controls ( n = 61). The (mean ± SD) insulin sensitivity index, as assessed by the Minimal Model method, was significantly lower in the HTG compared with the NTG group (3.69 ±2.96 vs. 6.29 ± 3.38 times 10 ‐4 min ‐1 per mUL ‐1 ; P < 0.001). Thirty‐eight per cent of the HTG group was glucose intolerant, compared with 8% in the NTG group (X 2 = 13.16; P <0.001). The glucose intolerant HTG sub‐group had, when compared with the glucose tolerant one, significantly higher serum concentrations of apoB (1318±284 vs. 1094±312mgL ‐1 ; P <0.01) and glycerol (84 ±26 vs. 65±22 nmolL ‐1 ; P <0.01). Serum FFA concentrations were, irrespective of glucose tolerance/intolerance, higher in the HTG than in the NTG group. By logistic regression analysis with the HTG/NTG state as the dichotomous variable, it was found that neither a low insulin sensitivity, nor glucose intolerance were independently linked with the HTG state. Instead, the lower insulin sensitivity of the HTG group was related to their higher body mass index. The higher frequency of glucose intolerance in the HTG group was explained by their higher mean serum apoB concentration, when compared with the NTG group. In conclusion, this study of a randomly selected HTG group has confirmed the frequent coexistence of HTG, insulin resistance and glucose intolerance. The new important finding was that neither of these two latter conditions appear to be of direct pathogenetic importance for HTG.