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Urodilatin (Ularitide, INN): a potent bronchodilator in asthmatic subjects
Author(s) -
FLÜGE T.,
FABEL H.,
WAGNER T.O.F.,
SCHNEIDER B.,
FORSSMANN W. G.
Publication year - 1995
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1995.tb01951.x
Subject(s) - bronchodilator , medicine , bronchodilator agents , asthma , pharmacology
Abstract. Atrial natriuretic peptide (CDD/ANP‐99–126) has been identified as a bronchodilator in various species including humans. We investigated the effect of urodilatin (CDD/ANP‐95–126) in 18 clinically stable asthmatics showing an increase of the FEV 1 by ≥15% after salbutamol inhalation. Prior to the study inhaled β 2 ‐agonists were withheld for 8 h. After baseline measurements of lung function parameters (FEV 1 , VC, PEF, MEF 75 , MEF 50 , MEF 25 ), blood pressure, and heart rate in intravenous infusion of 20, 40 or 60 ng kg ‐1 min ‐1 urodilatin was administered for 40min in the morning. All measurements were repeated every 10 min during the infusion, for 30 min thereafter, and after the inhalation of l.25 mg salbutamol. Forty and 60 ng kg ‐1 min ‐1 urodilatin showed a significant effect on the central (FEV l , PEF, MEF 75 ) and peripheral airways (MEF 50 , MEF 25 ) after 10 min infusion ( P <0.05). A broncho‐dilation not significantly different from l.25 mg salbutamol was induced by 40 ng kg ‐1 min ‐1 in the central airways only, while 60 ng kg ‐1 min ‐1 led to a similar effect at all levels of the bronchial tree. Lung function parameters returned to baseline within 30 min after cessation of the urodilatin infusion. Heart rate showed a tendency to increase after 40min infusion ( P <0.05), but blood pressure did not change significantly. In conclusion, the maximal bronchodilating effect of intravenous urodilatin in clinically stable asthmatics was comparable to l.25 mg salbutamol.