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Increased erythrocyte calcium pump activity in a kindred with familial benign hypercalcaemia
Author(s) -
ESCOBALES N.,
FARIÑAS C. A.,
HADDOCK L.
Publication year - 1995
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1995.tb01717.x
Subject(s) - hypercalcaemia , calcium , endocrinology , medicine
. The hypothesis that a global defect in cellular calcium transport may be critical in the development of familial benign hypercalcaemia (FBH) was investigated. Nine hypercalcaemic patients from a kindred with FBH and nine normal subjects were evaluated. Our results indicate that calcium pump activity in the FBH kindred was significantly higher (28%, P < 0.005) when compared to normal subjects. These findings suggest that alterations in calcium pump activity in activity in target tissues may play a role in the development of FBH.