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Testosterone treatment enhances thromboxane A 2 mimetic induced coronary artery vasoconstriction in guinea pigs
Author(s) -
SCHRÖR K.,
MORINELLI T. A.,
MASUDA A.,
MATSUDA K.,
MATHUR R. S.,
HALUSHKA P. V.
Publication year - 1994
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1994.tb02428.x
Subject(s) - testosterone (patch) , medicine , vasoconstriction , endocrinology , guinea pig , thromboxane , thromboxane a2 , agonist , androgen , artery , cardiology , receptor , platelet , hormone
. Thromboxane A 2 (TXA 2 ) has been implicated as an important mediator of cardiovascular diseases. There have been several clinical reports of acute myocardial infarctions occurring in young male athletes abusing anabolic steroids. The effects of treatment of male Guinea pigs with testosterone on the responses to U46619, a TXA 2 receptor agonist, in the isolated perfused heart were determined. The maximum pressor responses of the isolated perfused Guinea pig heart to U46619 were significantly ( P < 0·05) greater in the Guinea pigs treated with testosterone compared to the controls. These results indicate that testosterone can enhance coronary artery vascular reactivity to TXA 2 .