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Effects of lithium on bone resorption in cultured foetal rat long‐bones
Author(s) -
PEPERSACK T.,
CORVILAIN J.,
BERGMANN P.
Publication year - 1994
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1994.tb02183.x
Subject(s) - resorption , bone resorption , endocrinology , medicine , chemistry , stimulation , prostaglandin e2 , lithium (medication)
. Increased serum calcium has been observed in manic depressive patients treated with lithium (Li), and one of the mechanisms increasing serum calcium could be a sensitizing effect of Li on bone resorption. In a previous study, however, Li has been found slightly to inhibit PTH‐stimulated resorption in cultured foetal rat long‐bones. In this work, we extended the study of the effects of Li on bone resorption in culture when resorption of foetal rat long‐bones was stimulated by factors other than PTH. Li 3 mM had no effect on basal resorption, a slight and inconsistent inhibitory effect on PTH stimulated bone resorption, a moderate and inconstant inhibitory effect on prostaglandin E2 (PGE2) stimulated resorption, and did not significantly affect the enhancement of resorption by interleukin 1 (ILI). The more constant effect of Li was a nearly complete inhibition of the resorption response to 1,25‐dihydroxycholecalciferol (1,25(OH) 2 D 3 ). This study confirms that Li has no stimulatory effect on bone resorption by itself, nor a sensitizing action on the stimulation of resorption by several activators. Conversely, Li has a striking inhibitory effect on bone resorption stimulated by 1,25(OH) 2 D 3 .