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Erythrocyte Na + ‐H + exchanger and Na + ‐Li + countertransport activity in primary aldosteronism
Author(s) -
DELVA P.,
PASTORI C.,
DEGAN M.,
MONTESI G.,
BASSI A.,
LECHI A.
Publication year - 1994
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1994.tb02021.x
Subject(s) - primary aldosteronism , chemistry , endocrinology , medicine , aldosterone
. Several authors have described increased Na‐H exchanger activity in essential hypertension but no data are available in secondary forms of hypertension such as primary aldosteronism. We measured Na‐H exchanger kinetics together with Na‐Li countertransport V max in the erythrocytes of eight patients with primary aldosteronism and in 15 normotensive control subjects. Plasma aldosterone, plasma renin and plasma potassium were also evaluated. Na‐H exchanger V max appear to be increased in patients with primary aldosteronism and Hill's n , an index of co‐operativity amongst intracellular proton binding sites, was significantly lower in patients than in controls. No statistically significant differences were found between affinity for intracellular protons (K50%) and for Na‐Li countertransport V max between the two groups studied. We were unable to find any correlations between Na‐H exchanger V max and Na‐Li countertransport V max in the two groups considered as a whole. From the present data Na‐H exchanger overactivity would not appear to be a specific feature of essential hypertension but seems to be characteristic in patients with primary aldosteronism.