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Abdominal rubber drain piece aggravates intra‐abdominal sepsis in the rat
Author(s) -
GUO W.,
SOLTESZ V.,
DING JIN WEN,
WILLÉN R.,
LIU XIAOYING,
ANDERSSON R.,
BENGMARK S.
Publication year - 1994
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1994.tb01104.x
Subject(s) - cecum , peritoneal cavity , saline , mesenteric lymph nodes , abdominal cavity , medicine , peritoneum , chromosomal translocation , bacterial translocation , gastroenterology , ileum , sepsis , inflammatory response , laparotomy , surgery , spleen , inflammation , biology , biochemistry , gene
. Biomaterials in the peritoneal cavity disrupt the physiology of the host and may cause bacterial translocation. The current study was performed to determine whether biomaterials exacerbate intraabdominal infections. Adult male rats were divided into four groups: group 1, celiotomy + intraperitoneal (i.p.) saline; group 2, celiotomy + i.p. Escherichia coli (3 times 10 8 cfu); group 3, i.p. rubber + i.p. saline; and group 4, i.p. rubber + i.p. E. coli (3 times 10 8 cfu). Twelve h after the challenge, enteric bacterial translocation, bacterial population levels in the cecum and serum levels of IL‐6 and TNF were measured. Bacterial translocation to mesenteric lymph nodes and the liver was observed in animals from groups 2 and 3, but significantly increased in group 4 with a concomitant elevation of serum levels of TNF and IL‐6, as compared with group 1. Histological examination revealed a more pronounced inflammatory reaction in the peritoneum and distal ileum in group 4 than in groups 2 and 3. These results suggest that the presence of rubbers in the peritoneal cavity aggravates intraabdominal sepsis.