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Effect of endogenous organic hyperinsulinaemia on blood pressure and serum triglycerides
Author(s) -
VETTOR R.,
MAZZONETTO P.,
MACOR C.,
SCANDELLARI C.,
FEDERSPIL G.
Publication year - 1994
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1994.tb01096.x
Subject(s) - endogeny , blood pressure , medicine , endocrinology , blood lipids , cholesterol
Hyperinsulinaemia and insulin resistance have been hypothesized to be the common pathophy‐siological factor of hypertension, NIDDM and obesity. To evaluate the possible role of hyperinsulinaemia and insulin resistance on hypertension, we studied a group of 37 patients with insulinoma who were admitted to our department in the period from 1966 to 1990. We recorded blood pressure and assayed blood glucose, plasma insulin, plasma triglycerides and serum uric acid levels, before and after surgery, in these patients and in a 37‐subject control group. No significant increase in blood pressure and triglyceride plasma levels was recorded in the chronic hyperinsulinaemic hypoglycaemic patients, suggesting the lack of a direct role of hyperinsulinaemia on hypertension.