Premium
T‐cell receptor gene rearrangements in lymphoid and non‐lymphoid leukaemias
Author(s) -
CASARES S.,
RODRIGUEZ J. M.,
MARTIN A.,
PARRADO A.
Publication year - 1994
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1994.tb00976.x
Subject(s) - immunophenotyping , gene rearrangement , t cell receptor , myeloid , biology , lineage (genetic) , cancer research , t cell , immunology , gene , antigen , genetics , immune system
Abstract. Rearrangements of δ ‐, Γ ‐, and β ‐ T‐cell receptor (TcR) chain genes were analysed in 64 haematologic malignancies comprising T‐ and B‐lineage acute lymphoblastic leukaemias (ALL), B‐chronic lymphocytic leukaemias (CLL), acute myeloid leukaemias (AML) and acute undifferentiated leukaemias (AUL). The TcR genes were rearranged in 5/6 T‐ALL. In non‐T‐leukaemias the frequency of TcR gene rearrangements was higher in B‐lineage ALL (8/11), although they were all detected in B‐CLL (5/29), AML (1/16) and AUL (2/4). Immunoglobulin (Ig) gene rearrangements were observed in 1/6 T‐ALL and 2/14 AML. The analysis of these gene configurations has a diagnostic application since it allows the definition of the clonality of malignant proliferation and although they are not lineage specific such configurations represent a further parameter to evaluate, together with the immunophenotype and morphology, in the assignment or exclusion of the differentiation lineage of the haematologic malignancies.