Premium
Forearm muscle metabolism in primary hypothyroidism
Author(s) -
HARRIS P. E.,
WALKER M.,
CLARK F.,
HOME P. D.,
ALBERT K. G. M. M.
Publication year - 1993
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1993.tb00970.x
Subject(s) - medicine , endocrinology , euthyroid , skeletal muscle , carbohydrate metabolism , lipid metabolism , forearm , metabolism , thyroid , insulin , surgery
. Thyrotoxicosis is associated with increased skeletal muscle glucose metabolism and lipid oxidation in the fasted state. Conversely, in hypothyroidism, glucose metabolism is reduced. The present study has assessed in patients the effects of chronic thyroid hormone deficiency, on insulin‐stimulated skeletal muscle metabolism, using a combination of the fore arm and hyperinsulinaemic euglycaemic clamp techniques. Seven female patients presenting with primary auto‐immune hypothyroidism were studied at presentation and 4–9 months after being rendered bio chemically euthyroid. No significant differences were demonstrated between the hypothroid and euthyroid states in forearm muscle blood flow, or in glucose or lipid metabolism.