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Effect of IgM‐enriched intravenous immunoglobulin (Pentaglobin) on endotoxaemia and anti‐endotoxin antibodies in bone marrow transplantation
Author(s) -
JACKSON S. K.,
PARTON J.,
BARNES R. A.,
POYNTON C. H.,
FEGAN C.
Publication year - 1993
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1993.tb00963.x
Subject(s) - antibody , medicine , immunology , bone marrow , immunoglobulin m , transplantation , immunoglobulin a , intravenous immunoglobulins , gastroenterology , immunoglobulin g
. Endotoxin was measured in over 1000 plasma samples from bone marrow transplant patients in a randomized trial of the IgM‐enriched intravenous immunoglobulin (IVIG) Pentaglobin. Peak endotox aemia was significantly reduced ( P = 0.02) in patients receiving Pentaglobin and 70% of all pyrexias of unknown origin were associated with endotoxaemia. Gut mucosal damage, assessed by lactulose/mannitol ratios, was significantly associated ( P = 0.02) with endotoxaemia. Specific IgM antibody to endotoxin core‐glycolipid was significantly raised ( P <0.01) in patients receiving the IVIG, and the IgM fraction of Pentaglobin was found to contain most of the antiendotoxin antibody activity of the IVIG. These results suggest a role for IgM‐enriched WIG as a prophylactic agent for the reduction of endotoxaemia and its consequences in bone marrow transplant patients.