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Effects of acute respiratory acidosis on water and electrolyte transport in the human ileum
Author(s) -
EHERER A.J.,
PETRITSCH W.,
BERGER J.,
HINTERLEITNER T.,
CHARNEY A. N.,
KREJS G.J.
Publication year - 1993
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1993.tb00763.x
Subject(s) - respiratory acidosis , ileum , electrolyte , acidosis , respiratory system , electrolyte imbalance , medicine , anesthesia , chemistry , electrode
. Animal experiments have shown that acute respiratory acidosis stimulates water, Na and C1 absorption and HCO 3 secretion in the ileum. The aim of this study was to investigate whether the human ileum also responds to changes in systemic acid‐base balance. Seven healthy volunteers (mean age 24, range 21–29 years) underwent segmental ilea perfusion using a multi‐lumen tube assembly with a proximal occluding balloon. A 30 cm test segment was perfused under steady state conditions with a plasma‐like electrolyte solution containing PEG as a non‐absorb‐able volume marker. After a control period, respiratory acidosis (blood pCO 2 56.2 mmHg, pH 7.29 and [HCO 3 ] 26.4 mmol 1 ‐1 ) was induced by CO 2 ‐breathing over a period of 50 min. Acute respiratory acidosis stimulated net HCO 3 secretion in patients secreting HCO 3 and reduced absorption in patients exhibiting net HCO 3 absorption. These changes were immediate and appeared to be at least partly reversible. Net water, Na, K and CI movement were not affected. The data suggest that HCO 3 transport in the human ileum responds to acute respiratory acidosis.