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Fc‐Gamma receptor III shedding by polymorphonucIear cells in primary Sjögren's syndrome
Author(s) -
LAMOUR A.,
SOUBRANE C.,
ICHEN M.,
PENNEC Y. L.,
KHAYAT D.,
YOUINOU P.
Publication year - 1993
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1993.tb00747.x
Subject(s) - phagocytosis , receptor , monoclonal antibody , immune system , immunology , antibody , fc receptor , chemotaxis , microbiology and biotechnology , medicine , chemistry , endocrinology , biology
. A sandwich enzyme‐linked immunosorbent assay was developed to assess Fc‐gamma receptor III (Fc γ RIII), based on a combination of two non‐competing monoclonal antibodies. This receptor was detectable in the serum of eight out of 23 patients with primary Sjögren's syndrome and two out of 23 normal controls. The proportion of FcγRIII‐carrying polymorphonuclear (PMN) cells was lower (P < 0.05) in the patients with cell‐free Fc γ RIII (90·4 ± 7.5%) than in the remainder (84.8 ± 8.3%). The PMN cell functions were evaluated and the diminished adherence (71.7, geometric mean) and chemotaxis (1.23) paralleled the Fc γ RIII release. The relative inefficiency of PMN cells in SS might be due to phagocytosis of immune complexes.