Premium
Evaluation of the 13 CO 2 kinetics in humans after oral application of sodium bicarbonate as a model for breath testing
Author(s) -
MEINEKE I.,
MEY C. DE,
EGGERS R.,
BAUER F. E.
Publication year - 1993
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1993.tb00746.x
Subject(s) - sodium bicarbonate , bicarbonate , chemistry , kinetics , exhalation , carbon dioxide , sodium , radiochemistry , breath test , medicine , anesthesia , organic chemistry , physics , quantum mechanics , helicobacter pylori
. The kinetics of 13 CO 2 have been investigated following oral administration at five doses between 12.5 and 100 mg of 13 C labelled sodium bicarbonate to 10 healthy subjects in a randomized study. Sodium bicarbonate in this study served as a model compound for carbon dioxide/bicarbonate generated in breath tests. Exhalation of 13 CO 2 into breath was monitored by stable isotope ratio mass spectrometry. The kinetics of 13 CO 2 were characterized by an apparent terminal elimination half‐life of 1 h and a mean recovery of 0.630 of the dose administered. The kinetics were not dose‐dependent. These results were in agreement with the findings reported previously after iv. application of sodium bicarbonate.