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Suppression of lipolysis in normal man does not inhibit recovery from insuIin‐induced hypoglycaemia
Author(s) -
NEWRICK P. G.,
BRAATVEDT G.,
STANSBIE D.,
CORRALL R. J. M.
Publication year - 1993
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1993.tb00717.x
Subject(s) - lipolysis , medicine , endocrinology , placebo , adipose tissue , alternative medicine , pathology
. Pharmacological suppression of lipolysis is being increasingly used in the treatment of diabetic hyperlipidaemia. Although theoretical hazard of such treatment is that recovery from hypoglycaemia might be impaired. Seven normal subjects were theretore studied on two occasions, following treatment with a single dose of either acipimox 250 mg or placebo. Hypoglycaemic recovery was unaffected, despite effective suppression of plasma non‐esterified fatty acid levels with acipimox. The results suggest that under these conditions activation of lipolysis may not be essential to recovery from hypoglycaemia.