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Effect of endothelin‐1 in man: pretreatment with nifedipine, with indomethacin and with cyclosporine A
Author(s) -
VIERHAPPER H.,
WAGNER O. F.,
NOWOTNY P.,
WALDHÄUSL W.
Publication year - 1992
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1992.tb01936.x
Subject(s) - nifedipine , endothelin receptor , antagonist , blood pressure , endothelin 1 , medicine , endocrinology , pharmacology , calcium , receptor
. The rise in blood pressure following the intravenous administration of endothelin‐1 remained unchanged in healthy male volunteers pretreated with either the calcium‐channel antagonist nifedipine (10 mg orally), the cyclo‐oxygenase inhibitor indomethacin (150 mg day ‐1 for three days) or the immunosup‐pressive agent cyclosporine (5 mg kg ‐1 body weight for five days). Following administration of nifedipine the rise in plasma concentrations of endothelin‐1 during the infusion of the peptide was markedly higher ( P <0.01) than during control experiments without nifedipine. It is concluded that, in healthy men, nifedipine, indomethacin and cyclosporine do not exert a major influence on the pressor action of endothelin‐1. However, nifedipine apparently influences the elimination of endothelin‐1 from the circulation in healthy men.