Premium
Determinants of fasting plasma triglyceride levels: metabolism of hepatic and intestinal lipoproteins
Author(s) -
CORTNER J. A.,
LE N.A.,
COATES P. M.,
BENNETT M. J.,
CRYER D. R.
Publication year - 1992
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1992.tb01821.x
Subject(s) - chylomicron , medicine , triglyceride , endocrinology , chemistry , apolipoprotein b , lipoprotein , very low density lipoprotein , cholesterol , biology
. The contribution of the kinetics of exogen‐eous and endogenous lipoproteins in determining the level of triglyceride in fasting plasma was assessed in a group of 19 normolipidaemic and hypertriglyceridae‐mic subjects. From data derived during a 9‐h infusion of [ 15 N]‐glycine, we have assessed very low density lipoprotein apolipoprotein B production, and from data analysed by kinetic modelling obtained following ingestion of retinol and triolein, we have assessed chylomicron and chylomicron remnant clearance in a group of 19 normolipidaemic and hypertriglyceridae‐mic subjects. A strong positive correlation was observed between the fasting plasma triglyceride level and the reciprocal of the apolipoprotein B fractional synthetic rate ( r = 0.83, P <0.01). A positive correlation was also found with the rate of clearance of chylomicron remnants (S f 20–400; r = 0.87, P <0.01) and of chylomicrons (S f 400; r = 0.69, P < 0.01). No correlation was found between the fasting plasma triglyceride level and either of the plasma post‐heparin lipolytic activities. Multivariate analysis revealed that 95% of the variance in triglyceride levels could be explained by the apolipoprotein B fractional synthetic rate and the chylomicron remnant clearance rate. The strong correlation between chylomicron remnant clearance, a measure of exogenous lipid metabolism, and fasting (hence, endogenous) plasma triglyceride levels suggests that remnants of chylomicrons and very low density lipoproteins share some common components of the removal process.