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Verapamil increases serum ionized calcium and serum phosphate in patients with post‐surgical hypoparathyroidism
Author(s) -
SJÖDÉN G.,
ROSENQVIST M.,
NORDENSTRÖM J.,
BJÖRKHEM I.,
ERIKSSON S. A. V.,
KRIEGHOLM E.
Publication year - 1992
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1992.tb01477.x
Subject(s) - verapamil , medicine , endocrinology , calcium , hypoparathyroidism , calcium metabolism , parathyroid hormone , excretion , chemistry , creatinine , urinary calcium
. The calcium homeostasis in eight patients with postoperative hypoparathyroidism was examined before and after 2 weeks of administration of verapamil in an oral dose of 80 mg three times daily. Serum ionized calcium increased during verapamil treatment (from mean ± SD of 110 ± 006 to 1.24 ± 0.38 mmol 1 ‐1 ; P <0.05), as well as total serum calcium corrected for protein (from 2.11±0.13 to 2.18 ± 0.13 mmol l ‐1 ; P < 0.05). During treatment with verapamil there was an increase in serum phosphate (from 1.08 ±0.15 to 1.19±0.20 mmol l ‐1 P ≤ 0.05) and in the urinary excretion of phosphate ( P /creatinine ratio from 1.22±0.69 to 1.83 ± 0.97; P ≤0.05). The serum 1,25‐dihydroxyvitamin‐Dj and serum parathyroid hormone were below the detection limits both before and after verapamil treatment. There were no significant changes either of the intestinal absorption of calcium or of the urinary calcium excretion. Serum osteocalcin was insignificantly reduced after treatment (1.60 ± 0.70 before treatment and 1.25 ± 0.71 μg l ‐1 after treatment). Thus in patients with post‐surgical hypoparathyroidism verapamil has effects on calcium and phosphorous homeostasis. Since calcium absorption was not influenced by verapamil, it is suggested that verapamil affects bone mineral metabolism.