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Identification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumours
Author(s) -
SCHWEIGERER L.,
CHRISTELEIT K.,
FLEISCHMANN G.,
ADLERCREUTZ H.,
WÄhÄlÄ K.,
HASE T.,
SCHWAB M.,
LUDWIG R.,
FOTSIS T.
Publication year - 1992
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1992.tb01460.x
Subject(s) - genistein , neuroblastoma , urine , cell growth , chemistry , cell culture , pharmacology , endocrinology , medicine , biology , biochemistry , genetics
. Partially purified urine of healthy human subjects contains several fractions able to inhibit the proliferation of cultured human neuroblastoma cells. One of the most active fractions was further analysed by gas chromatography‐mass spectrometry and shown to contain genistein, a substance formed in the human body from precursors obtained by diet. Synthetic genistein was able to inhibit the proliferation of human neuroblastoma cells with a half‐maximal effect at 5–10 μmol 1 ‐1 concentrations. Genistein displayed similar potencies in inhibiting the proliferation of cells derived from various other solid pediatric tumours. Our results suggest that genistein is a natural antineo‐plastic agent present in diet and that it could be useful for the therapy of paediatric tumours.