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Prolonged sleep‐deprivation induced disturbed liver functions serum lipid levels, and hyperphosphatemia
Author(s) -
ILAN Y.,
MARTINOWITZ G.,
ABRAMSKY O.,
GLAZER G.,
LAVIE P.
Publication year - 1992
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1992.tb01438.x
Subject(s) - morning , evening , medicine , endocrinology , sleep deprivation , triglyceride , hyperphosphatemia , apolipoprotein b , circadian rhythm , cholesterol , calcium , physics , astronomy
. Sixty‐four healthy young male volunteers were kept awake from 76 to 80 h. Blood tests conducted at the start and conclusion of the continuous sleep deprivation revealed an increase of 170% in mean SGOT, 58–5% in mean SGPT and 37–5% in mean plasma phosphorus levels. Triglyceride levels decreased by 16%, while HDL levels increased by 18% and the apoB/apoA ratio decreased by 12%. Morning plasma cortisol showed a significant increase during the experiment while evening cortisol showed a significant decrease. Morning T3 levels increased from the first to second day and decreased on the third day. There were no significant changes in other plasma electrolyte levels.