Premium
Alveolar macrophage chemotaxis in fire victims with smoke inhalation and burns injury
Author(s) -
RIYAMI B. M. S.,
KINSELLA J.,
POLLOK A. J.,
CLARK C.,
STEVENSON R. D.,
REID W. H.,
CAMPBELL D.,
GEMMELL C. G.
Publication year - 1991
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1991.tb01399.x
Subject(s) - alveolar macrophage , smoke inhalation , smoke inhalation injury , inhalation , medicine , smoke , macrophage , chemotaxis , poison control , medical emergency , immunology , chemistry , anesthesia , in vitro , biochemistry , receptor , organic chemistry
.In vitro migration of alveolar macrophages was studied in 24 fire victims and 19 controls; all subjects were cigarette smokers. Unstimulated ( p = 0·01) and stimulated migration towards casein‐( P = 0·01) and zymosan‐activated serum ( P = 0·002) of macrophages from smoke inhalation patients (SI) ( n =19) was increased when compared to control subjects (CS). Migration of alveolar macrophages from patients with burns without smoke inhalation (burns only, BO) was not increased. Patients with smoke inhalation and no burns (smoke only, SO) ( n = 9) had increased migration when compared to controls but this was not statistically significant. Patients with smoke inhalation and burns (SB) ( n = 10) had increased unstimulated migration ( P = 0·01) and increased migration towards casein ( P <0·005), ZAS ( P <0·002) and F‐met‐leu‐phe ( P <0·05) when compared to controls (CS). Lavage fluid from the fire victims displayed chemotactic activity towards normal human neutrophils and its analysis for the components of the complement cascade proved positive (C lq , C lr , Factor B and C 3 3). These data suggest that activation of alveolar macrophages may contribute to the development of pathophysiological changes in patients with smoke inhalation (SI) and particularly those with smoke inhalation and burns (SB).