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The effects of low dose insulin infusions on the renin angiotensin and sympathetic nervous systems in normal man
Author(s) -
ROONEY D. P.,
EDGAR J. D. M.,
SHERIDAN B.,
ATKINSON A. B.,
BELL P. M.
Publication year - 1991
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1991.tb01391.x
Subject(s) - endocrinology , medicine , insulin , plasma renin activity , renin–angiotensin system , sympathetic nervous system , angiotensin ii , aldosterone , chemistry , clamp , blood pressure , mechanical engineering , clamping , engineering
Abstract. To examine the effects of physiological insulin concentrations on the renin‐angiotensin and sympathetic nervous systems, healthy volunteers were studied by the euglycaemic glucose clamp technique with sequential 60 min 0·5 and 1·0 mU kg ‐1 min ‐1 insulin infusions and, subsequently, by a control infusion simulating clamp conditions. Plasma renin activity increased from 0·8 ± 0·1 ng ml ‐1 h ‐1 basally to 1·0 ± 0·2 ng ml ‐1 h ‐1 during the 0·5 mU infusion to 1·4 ± 0·1 ng ml ‐1 h ‐1 during the 1 mU infusion but did not change during control infusion (0·9 ± 0·3 ng ml ‐1 h‐1 to 0·9 ± 0·2 ng ml ‐1 h ‐1 to 1·0 ± 0·1 ng ml ‐1 h ‐l ) ( P <0·001 insulin vs. control by ANOVAR). Plasma angiotensin II increased during insulin (21·2 ± 1·8 to 25·2 ± 2·3 to 29·3 ± 2·4 pg ml ‐1 ) but not during control infusion (24·0 ± 2·8 to 23·6 ± 2·6 to 23·5 ± 2·5 pg ml ‐1 ) ( P <0·001 insulin vs. control). Serum aldosterone did not change significantly during either infusion (insulin: 239 ± 89 pmol 1 ‐1 to 237 ± 50 pmol 1 ‐1 to 231 ± 97 pmol 1 ‐1 , control: 222 ± 79 to 237 ± 50 to 213 ± 97 pmol 1 ‐1 ). Plasma noradrenaline increased to a greater extent during insulin (1·03 ± 0·2 to 1·14 ± 0·8 to 1·27 ± 0·17 nmol 1 ‐1 ) than control infusion (0·86 ± 0·09 to 0·97 ± 0·09 to 0·99 ± 0·09 nmol 1 ‐1 ( P <0·01 insulin vs. control). Changes in mean systolic blood pressure during insulin infusion were significantly different from control (+3 vs.‐4 mmHg, P <0·001). In conclusion acute hyperinsulinaemia within the physiological range increases circulating hormones of the renin‐angiotensin and sympathetic nervous sytems and also increases systolic blood pressure.