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n‐3 fatty acids and acute‐phase proteins
Author(s) -
ERNST E.,
SARADETH T.,
ACHHAMMER G.
Publication year - 1991
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1991.tb01362.x
Subject(s) - acute phase protein , haptoglobin , macroglobulin , fibrinogen , medicine , endocrinology , glycoprotein , eicosapentaenoic acid , blood proteins , antibody , chemistry , docosahexaenoic acid , fatty acid , biochemistry , immunology , inflammation , polyunsaturated fatty acid
. The aim of this study was to determine the effects of n‐3 fatty acids on acute‐phase proteins and response. Healthy male volunteers were submitted to standard bicycle ergometry once without supplementation and a second time after 3‐weeks supplementation with highly purified n‐3 fatty acids (1.75 g eicosapentaenoic acid and 1.05 g docosahexaenoic acid per day). Acute‐phase proteins (immunoglobulin M, complement C4, haptoglobin, C‐reactive protein, a2‐macroglobulin, coerulopasmin, fibrinogen, α 1 ‐glycoprotein) were measured before, immediately after, 24 and 72 h after exercise. There were significantly lower values of immunoglobulin M (pre‐exercise and at 72 h) and α 2 ‐macroglobulin (pre‐exercise) when cross‐sectionally comparing the baseline data with and without n‐3 supplementation. Longitudinal comparisons show that the ergometric test induced a discrete acute‐phase reaction, which is evident with and without n‐3 fatty acids. Yet the kinetics of the response seem to be altered by n‐3 supplementation. The relative increase of most acute‐phase proteins is numerically larger and the rise persists longer, which is particularly evident for fibrinogen and α 1 ‐glycoprotein. The findings suggest that n‐3 fatty acids lower acute‐phase proteins at baseline and alter the pattern of change following acute exercise.