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Skin microcirculation and regional peripheral resistance in patients with chronic renal anaemia treated with recombinant human erythropoietin
Author(s) -
CREUTZIG A.,
CASPARY L.,
NASTDANIEL B.,
BAHLMANN J.,
KÜHN K.,
BRUNKHORST R.,
REIMERS E.,
KOCH K. M.,
ALEXANDER K.
Publication year - 1990
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1990.tb02272.x
Subject(s) - erythropoietin , microcirculation , medicine , vascular resistance , peripheral , pathological , peripheral resistance , blood pressure , oxygenation , blood flow , cardiology , cardiac output
Skin microcirculation and regional peripheral resistance were studied in 14 patients with renal anaemia during therapy with recombinant human erythropoietin. Haematocrit was raised from 20·0 to 31·3% after 10–12 weeks of treatment and remained stable over another period of 12 weeks. Antihypertensive treatment had to be intensified in five patients. Regional calf blood flow decreased significantly; accordingly, calculated peripheral vascular resistance was increased by more than 100%. However, transcutaneous oxygen pressure (37°C and 44°C) increased significantly. The pathological vasoconstrictor response of skin capillaries was not influenced. There were no significant differences of any parameter between the patients requiring reinforced antihypertensive therapy and those with stable blood pressure. In conclusion skin oxygenation may be improved by erythropoietin treatment to a large extent despite an increase in calculated total limb vascular resistance.