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Follow‐up of the serum levels of extracellular matrix components in acute and chronic pancreatitis
Author(s) -
ADLER G.,
KROPF J.,
GROBE E.,
GRESSNER A. M.
Publication year - 1990
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1990.tb01891.x
Subject(s) - acute pancreatitis , pancreatitis , laminin , hyaluronic acid , medicine , fibronectin , gastroenterology , extracellular matrix , sepsis , chemistry , biochemistry , anatomy
. Time‐dependent serum concentrations of extracellular matrix proteins were studied in 32 patients with pancreatitis in order to find potential markers of the reparative response during the disease. Patients were subdivided by clinical and biochemical criteria: severe acute pancreatitis ( n =10), moderate acute pancreatitis ( n = 17), and acute attack of chronic pancreatitis ( n = 5). Serum and plasma samples were collected on days 1–7, 10,14, and 21 for measurements of the aminoterminal propeptide of type III procolla‐gen (PIIINP), hyaluronic acid, laminin, fibronectin, and routine clinical‐chemical parameters. During an acute attack of chronic pancreatitis all parameters were within the reference range. In moderate acute pancreatitis concentrations of PIIINP, laminin, and hyaluronic acid fluctuated around the upper reference limit, but declined to mid‐normal levels at day 21. In severe acute pancreatitis all three parameters increased. In patients who died as a consequence of sepsis and multi‐organ failure the increase in PIIINP, laminin and hyaluronic acid was much more pronounced and paralleled by a decrease in plasma concentrations of fibronectin. In conclusion, this study revealed a relation between the severity of acute pancreatitis and the increase in serum concentrations of extracellular matrix components, especially PIIINP.